![]() ![]() The potential for RNA to form energetically similar conformations comes from the chemical simplicity of RNA molecules, whichĪre made up of combinations of nucleotides joined together by phosphodiester bonds. Structures and can therefore be regulated to be partitioned into distinct subpopulations, with each population giving rise Furthermore, we are justīeginning to understand that, unlike proteins, an RNA with a particular sequence has the potential to form entirely different We are just starting to fathom the depth and extent of the regulatory information contained in RNA. Although we have for a long time appreciated the direct relationship between RNA structures and the functions they regulate, Even ribosomal RNA (rRNA), the most abundant form of RNA in cells, samples alternate structures For example, in the case of mRNAs, these structural elements have been shown to regulateĮvery aspect of the mRNA’s voyage through the cell-from transcription, splicing, and nuclear export to trafficking, localization, RNA can fold into complex three-dimensional structures, enabling it to perform diverse biological functions beyond the simple RNA plays an important role in a large number of cellular processes, and, in many cases, it is the RNA that drives function. ![]() Previous Section Next Section 1 Introduction ![]()
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